A game Leeds will need to win if they are to be certain of heading into the last game with their destiny in their own hands.
It would take a bizarre set of circumstances for Charlton to clinch second spot but the game is equally important to them.
With sixth placed Huddersfield just a point behind with two winnable games to come, Charlton could easily find themselves facing Millwall or Leeds again in the initial stages of the play-offs.
Back in 1996 an unlikely Millwall draw at Ipswich was not enough to keep the Lions up, but did allow Charlton to make the play-offs, where they succumbed to Crystal Palace. Lions fans will be hoping Charlton can return the favour.
Jonjo Shlvey has left the club although he will not officially become a Liverpool player until 10 May. Sam Sodje looks to be winning his fitness battle and the Addicks could be unchanged.
Leeds have been in indifferent form since their stunning FA Cup victory at Old Trafford. Seemingly guaranteed the title at turn of the year, they now have a major fight on their hands to avoid the lottery of the play-offs.
Jermaine Beckford has been relegated to the bench recently with Arsenal loanee Sanchez Watt partnering Becchio up front.
Robert Snodgrass will pose a threat from the flank.
Premiership referee Lee Probert will be the man in charge.